science

At the HIV Vaccine World Congress, which is taking place in Barcelona between the 7^th and 10^th October, Catalan researchers presented a vaccine prototype that has proven to be effective in clinical studies conducted with mice and monkeys. The vaccine stimulates the creation of antibodies and attacks infected cells. The prototype has been created by the Catalan programme to develop a vaccine against HIV, HIVACAT. According to the programme’s Scientific Director, Christian Brander, the vaccine could eventually also be used as a therapeutic treatment.

According to a medical study developed in Barcelona’s Hospital Clínic, fetuses conceived by assisted reproduction have changes in their heart and arteries, which begin even before birth and persist in the postnatal period. These changes represent a significant increase in cardiovascular risk in adulthood. However, the researchers point out that this situation is reversible from the beginning of life through a diet rich in omega3 and other factors. In addition, they strongly emphasised that this is only a risk factor and not a disease. The study leader, Eduard Gratacós, said that “it's a message of opportunity, not alarm”. Furthermore, they also recommend monitoring the blood pressure of these babies.

The Catalan Institute of Photonic Sciences (ICFO), based in Greater Barcelona, is the highest ranked centre in the world in the fields of physics and astronomy, according to a survey carried out by Excellence Mapping. This ranking sorts the world’s leading research centres according to 17 different areas of academia. The ICFO was ranked first in physics and astronomy, while the Catalan Institute for Research and Advanced Studies (ICREA) was placed third in this category. Other Catalonia-based institutions that were included in the list were: the Institute for High Energy Physics, IFAE (18^th place), the Universitat Autònoma of Barcelona (UAB) and the Polytechnic University of Barcelona (UPC). The Director of the ICFO, Lluís Torner, told the CNA that the Catalan model of research is “highly competitive”.

Christian Brander is a researcher at the IrsiCaixa AIDS Research Institute and Scientific Director of HIVACAT, the programme for the development of a HIV vaccine. He graduated from the University of Bern in 1994 with a PhD in Immunology and has spent 13 years at Harvard University focusing on cellular immunity to viral infections.

The Catalan research centre has unveiled a new 625-square-metre space where the Academic Research Organisation (ARO) will be based. The ARO will provide support for clinical trials developed throughout the world regarding quality control, methodological, regulatory, statistical and management aspects. Furthermore, the new space has 7 medical boxes, nursery support and a lab to process the samples, which will provide an integral service for clinical trials. The new facilities will be able to host between 750 and 1,100 patients per year and work on 350 trials. It cost €1.2 million, which came from public funds.

50% of tumours are related to mutations of this gene, according to the researchers. A study developed by the Bellvitge Institute of Biomedical Research (IBIDELL), based in Greater Barcelona, and the University of Cincinnati have discovered the role of the noncoding 5S rRNA molecule. This molecule regulates the P53 Tumour Suppressor Gene, which protects healthy cells from turning into cancerous cells. When the cell functions correctly, the levels of P53 are low and stable, but when something wrong is detected, the levels increase and cause the cell’s death, avoiding the development of a tumour. The director of the study, George Thomas, explained that understanding how the P53 works and regulates itself is extremely important since “more than half of the tumours present mutations of this gene”.

The exposure to music during in vitro fertilisation has a positive impact on the fecundity rate of egg cells according to a study developed by the assisted reproduction centre Institut Marquès, based in Barcelona. The study concludes that the micro vibrations in the music shake the culture liquid in which the ovum swims and this improves the distribution of nutrients and also avoids the accumulation of toxic products. As a result, the fertilisation of the ovum is facilitated and the success rate is improved by 4.8%. Three styles of music were tested (pop, heavy metal and classical) but no significant differences were observed in relation to the different frequencies.

The Catalan Institute of Human Paleoecology and Social Evolution (IPHES) is one of the 3 centres with the highest scientific production internationally in its field. It is directed by Eudald Carbonell, the palaeontologist who has been directing the Atapuerca site since its discovery. Atapuerca was where the oldest human specimens in Europe were found, the so-called Homo Antecessor. The IPHES started its activities in 2006 but due to its increasing relevance it needed more room. Since last June the institute has moved to a new building in the Sescelades Campus of the Rovira i Virgili University (URV) in southern Catalonia. On Friday the President of the Catalan Government, Artur Mas, officially unveiled the facilities. The new building cost €6 million and it has 3,000 square metres to host 62 members of staff.

UNESCO has declared the Montsec mountain range, located in Western Catalonia, to be one of the world’s six Starlight Tourist Destinations for the excellent qualities of its night sky for astronomic observation. Only six spots in the world hold this distinction; three of them in Spain. The Starlight Foundation has plans for this distinction to be held by up to 15 spots at the most. The Montsec, located between the towns of Balaguer and Tremp, holds one of Southern Europe’s most important astronomic observatories: the Centre d'Observació de l'Univers, cooperating with the NASA. On the 21st of March, the diploma will be presented as well as some recommendations to keep the luminescent qualities and promote the area for astronomic tourism.

Between the 11th and 13th of March, Barcelona will host the spring meeting of Bio-Europe, the continent’s largest partnering conference of the global biotechnology industry, for the second time. 1,300 biomedical companies will participate in the event, with more than 2,000 delegates and executives. 60 out of the 100 Spanish companies attending are from Catalonia. In the last decade, Catalonia, particularly the Greater Barcelona area, has become the most important centre in Southern Europe within the biomedical field and one of the main centres internationally. Barcelona’s Deputy Mayor for Economic Affairs, Sònia Recasens, praised the importance of the event as it boosts those “added-value sectors that are strategic for the city’s economic growth”.

This is a real stride for the cancer research. The effects of a protein called condensing on colorectal cancer have been found out by a team of Molecular Biology and Biochemistry experts, at the Research Centre for Nanomedicine (CIBBIN-Nanomedicine) at the Vall d'Hebon Research Institute. The researchers have discovered that condensin helps the tumor cells to divide rapidly, so its inhibition leads to the death of tumour cells. The results of this research were published in the 'Journal of Biology and Chemistry', and they constitute a real hope for the fight against colorectal cancer.

Through its FET-Flagship programme, the European Commission is allocating €1 billion to each of the two main research projects in Europe. The first one is a project to explore the properties of graphene, a new material deriving from graphite that might revolutionise industry as silicon did a few decades ago. The second one will simulate a human brain in order to understand how it exactly works. The Catalan Institute of Nanotechnology is one of the nine leading institutes coordinating the graphene project, in which 623 research groups from 32 different countries will participate. Furthermore, the Barcelona Supercomputing Center will take care of the calculations at a molecular level in the Human Brain Project.

According to experiments tested on mice, Catalan scientists have affirmed that the stem cells located in the human umbilical chord, which are multipotential and therefore can become different types of cells, can be used to regenerate the tissue affected by a heart attack or a stroke. Until now the only way to recover the damaged tissue was through pharmacological treatment or a heart transplant.

The scientists working at the HIVACAT project for the development of an effective cure against the HIV virus are hopeful of finding a vaccine in the near future that would stop patients having to be treated for their whole life, actually eradicating the disease. The researchers have tested a first vaccine that has proved effective in reducing the viral load by up to 95%. However, the vaccine effects are only temporary, so researchers will continue the investigation in order to achieve a permanent effect.

The Barcelona-based Vall d’Hebron Research Institute (VHIR) has identified two proteins that block the metastasis of rhabdomyosarcoma, a type of cancer that represents 8% of this sort of illness in children. These two proteins are related to cellular proliferation and growth as well as having the capacity to migrate to other organs. The study opens the door to the development of new treatments targeting these two proteins. The study was funded by the foundation of the Catalan Public TV Broadcaster and it has been published in the British Journal of Cancer (BJC).