research centre

Researchers from the University of Barcelona (UB) and the Catalan capital’s CELLEX Biomedical Research Centre (IDIBAPS-UB) have found the essential role played by cholesterol in cell mobility and tissue invasion, which also means its role in cancer propagation. In fact, this research, led by Professor Carles Enrich, is a key study for better understanding of cancer metastasis – the process in which cancer cells invade healthy tissues – and progresses the discussion on the relationship between cholesterol levels and cancer incidence. The paper is published in open access ‘Cell Reports’. In short they found that the so-called “bad” cholesterol (LDL cells) promotes cell mobility while “good” cholesterol (HDL cells) avoids cell propagation. The study opens new therapeutic paths to blocking cancer metastasis.

Scientists at the Universitat Autònoma de Barcelona (UAB) have found that an alteration of a neuronal gene program plays an essential role in the first stages of Alzheimer's disease and have developed a gene therapy which is effective on mice. The Catalan study occupies the front page of 'The Journal of Neuroscience'. Researchers have identified a new mechanism that regulates the expression of genes in the brain which are essential for the function of neuronal circuits involved in learning and memory. According to the new study, which was carried out by Dr. Carlos Saura's group at the UAB's Institute of Neurosciences (Institut de Neurociències), the alteration of a gene program mediating neuronal transmission and survival may underlie memory loss at early pathological stages of Alzheimer's disease (AD).

Hewlett-Packard has announced that it will locate its world centre to develop 3D printing business in its facilities at Sant Cugat del Vallès, in Greater Barcelona, where it has already developed part of this technology. In fact, HP's Catalan offices are one of the multinational's main R&D centres at world level. HP also develops the technology for large-format printing in Greater Barcelona, employing some 350 engineers. In addition, it runs its marketing services for Europe, the Middle East and Africa from Catalonia. Now, HP has decided to foster its 3D printing business and Barcelona "will play a significant role", being the group's flagship for the research and development of this technology. HP explained that the main challenges engineers will have to face are the slow speed and low quality of the current 3D printing devices.

Barcelona’s Hospital Clínic has installed the ‘Micra’ 24mm pacemaker - equivalent to the size of a one euro coin -  in 4 patients as part of a clinical trial involving 10 medical centres and 60 patients troughout the world. This innovative wireless system is minimally invasive since it does not require any surgical procedure but is implanted in the heart through the femoral vein using a catheter. Such a procedure can be performed within 30 minutes and also reduces the patients’ risks of future infections. According to the Medical Director of the Hospital, Josep Brugada, if the clinical study is successful, it will involve a “paradigm shift”. Experts estimate it could reach hospitals within the next two or three years.

The Catalan Institute of Nanoscience and Nanotechnology (ICN2) has set up its new headquarters at the Universitat Autònoma de Barcelona (UAB) campus. The new faculties are located in a 6,000 square meter building with 40 laboratories, where scientific projects will be developed in different areas, from biomedicine to the development of everyday products such as paint or detergents.. This project is funded by both the Catalan and Spanish Governments and aims to make the centre a flagship in the European scientific field.

‘elBulli1846’, the ambitious initiative of acclaimed Chef Ferran Adrià, could well become a reality in March 2016 thanks to a €9 million investment made through the Catalan Chef’s foundation. The Catalan Government described such an initiative as “a national project”. ‘elBulli1846’ is named after the number of dishes created in the 3-Michelin-star El Bulli, which was awarded the world’s best restaurant on 5 occasions. Adrià’s new project is notably looking to establish a unique centre in the world for innovation, research, and training in the field of avant-garde cuisine. Besides, for 20 days a year, visitors will have access to ElBulli restaurant, with half of the available entrances awarded for free through a lottery. The centre will be located in the old restaurant’s venue in the Cap de Creus Natural Park (Costa Brava). 3,000 square metres will be added but built respecting the environment.

A clinical trial conducted in nine Catalan health care centres and published in the ‘British Medical Journal’ found that “in the case of mild respiratory infections such as acute bronchitis, there is a misuse of antibiotics, which is of no benefit to patients, and only helps increasing resistance to these drugs”. The study has been coordinated by the prestigious Vall d’Hebron Research Institute (VHIR). From 2010 to 2012, 416 patients, who showed several signs of acute bronchitis, were randomly assigned one of three different treatments. The main conclusion was that antibiotics, the most widely prescribed treatment for this type of illness, are ineffective. The study also showed that anti-inflammatory treatments increased in a minimal way the chances of ending coughs faster.

Referring to yesterday’s announcement, Carles Constante, the Director General for Regulation, Planning and Health Resources at the Catalan Ministry of Health, said that the Director of Barcelona’s Centre for Regenerative Medicine (CMRB), Juan Carlos Izpisúa had resigned due to the need for a more direct management. Constante explained that even though research centres now had a “high level of interconnection and ongoing dialogue”, they also needed “direction, management and a drive of energy within the centre itself, something that could be difficult to maintain from a distance”. Constante stressed that Izpisúa working from the United States for most of the time had been the main reason for him stepping down.

The Director of Barcelona’s Centre for Regenerative Medicine (CMRB), world-famous scientist Juan Carlos Izpisúa, resigned due to the lack of financial and political support from both Spanish and Catalan Governments. Such news was first published by Spanish newspaper ‘El País’ and then confirmed by sources in the research centre. Internationally, Izpisúa is considered to be one of the most esteemed and learned scientists in the field of stem cells. With the Director stepping down, the CMRB could well lose most of its current projects. Indeed, 18 of the 21 projects are the intellectual property of Izpisúa and might no longer be carried out in the Barcelona-based research centre if Izpisúa quit.

People who follow a Mediterranean diet enriched with extra virgin olive oil will reduce by 40% the risk of having diabetes, and by 18% if the diet is enriched with nuts. This is one of the main conclusions of a scientific study conducted by 18 research centres throughout Spain on 3,500 people. Jordi Salas-Salvadó, Director of this study, said that such results would change the usual perception of diabetes prevention. The Mediterranean diet is not solely efficient against diabetes. Indeed, the results showed that following such a diet also reduced by 30% the chances of contracting cardiovascular diseases.

The Catalan pharmaceutical company Grífols and Barcelona’s Alzheimer Treatment&Research Center of Fundació ACE – a family charity – have announced that they will run tests of a vaccine against this neurodegenerative illness from January 2014. It will target 365 Alzheimer’s patients at mild and moderate stages of the illness. The first investigation project that ACE’s centre will host is called Ambar. The 365 participants will be randomly divided into three treatment groups plus a fourth control group. The patients will come from 17 Spanish hospitals and 20 United States’ medical centres. From 1996, the ACE Foundation has evaluated more than 14,000 people, 47% of whom were diagnosed with Alzheimer’s. It has the largest bank of genetic data in Europe.

Doctor Joan Massagué has been appointed Scientific Director of the Sloan-Kettering Institute in New York , the world’s leading cancer research centre, which is part of the Memorial Sloan-Kettering Cancer Centre. The Catalan scientist has been chosen by an international expert committee and will take office on the 1^st of January 2014. The President and CEO of the Memorial Sloan-Kettering, Craig B. Thomson, said that Massagué had been given the job for his “exemplarity as a scientist” and because he is an “international leader” in the study of metastasis and factors regulating cell growth. This announcement follows last year’s appointment of another Catalan Doctor, Josep Baselga, as the Physician-in-Chief of the Memorial Sloan-Kettering Cancer Centre. Both Baselga and Massagué will continue to combine their responsibilities in New York with their research in Barcelona.

Researchers from Barcelona’s Centre for Regenerative Medicine (CMRB), the Catalan capital’s Hospital Clínic and the Salk Institute of California have successfully created three-dimensional renal structures which are virtually indistinguishable from embryonic kidneys. They have started creating kidney cells from human stem cells, and ultimately proven that these newly created cells could aggregate in vitro to form a “micro-kidney”. The team led by Juan Carlos Izpisúa, from the CMRB, said that this scientific breakthrough would facilitate the study of kidney diseases and enable scientists to work on new treatments. He added that this achievement was a great step towards developing therapies based on the use of stem cells.

The University of Lleida (Western Catalonia) will be leading the INNOSTORAGE Project regarding efficient thermal storage. They will focus their study on improving energy-storing by using Phase Change Materials and their temperature changes. The project, which is financed by the European Commission, aims at reducing CO2 emissions and saving energy by finding new efficient energy-storing systems. Thanks to the Marie Curie International Research Staff Exchange Scheme (IRSES), INNOSTORAGE brings together searchers from Catalonia, France, Israel, the United-States, Australia, and New-Zealand.

Researchers of Barcelona-based Vall d’Hebron Hospital and Research Institute discovered some of the main causes of the Idiopathic Pulmonary Fibrosis, which were unknown before today. Vall d’Hebron’s study showed that a continuous exposure to feather pillows and duvets was one of the main causes of this illness as it favours the scarring of lung tissue. This disease provokes a progressive decline of lung function and leads to asphyxia because of the deterioration of the organ’s tissue. The study has been able to trace the diseases’ causes in half of the studied cases. Besides feather pillows and duvets, the persistent exposure to fungus and close contact with birds can also trigger the illness. The Catalan research allows for a new approach to the illness’ prevention and its diagnosis in the early stages. It also represents a completely new approach to this pathology in terms of treatment.