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A new computational method allows the detection, within just a few hours, of the genetic alterations responsible for the formation and progression of cancer tumours. This new method manages to accurately identify almost all types of genetic changes of cancer cells in a simple, quick and precise way. It is also able to identify large-scale chromosome rearrangements, which had been difficult to be detect until this breakthrough. The new method, called SMUFIN, has been developed by the Barcelona Supercomputing Centre and the ICREA (Catalan Institution of Research and Advanced Studies), in collaboration with research groups from Barcelona, Oviedo and Heidelberg. This progress has been published by the prestigious journal 'Nature Biotechnology' and represents a significant step forward towards the personalised treatment of cancer and other illnesses.

The Catalan banking system boasts a strong image after the publication on Sunday of the 2014 EU-wide stress test results, issued by the European Banking Authority (EBA). All the financial entities based in Catalonia have sailed through the EBA stress test, showing they could face the most adverse economic developments with only their own resources. In the most difficult scenario, Barcelona-based CaixaBank – which is the largest bank in the Spanish market – reached a 9.3% equity ratio (CET1), Banc Sabadell got an 8.3% and Catalunya Banc an 8%. The minimum required was 5.5%, which was not reached by 24 of the 123 European banks analysed. Only one Spanish entity, Madrid-based Liberbank, would need additional capital in the worst case scenario.

The Spanish Government announced on Friday that it has asked its legal services to analyse all the aspects of Catalonia's alternative vote of the 9^th of November, which is replacing the original consultation vote that has already been banned by the Spanish authorities. 16 days before the consultation vote has to take place and 10 days after it was announced by the President of the Catalan Government, Artur Mas, the Spanish Executive is starting to pave the way for appealing against this new participatory process that asks Catalans their opinion about independence from Spain. On Friday, the Spanish Deputy Prime Minister, Soraya Sáenz de Santamaría, stated that Mas is pretending to replace "an illegal process for one that is even more antidemocratic". Therefore, it seems that after a few days hesitating whether or not to ban the new vote, the Spanish Government will probably appeal against it and make the Constitutional Court temporarily suspend it. In the last few days, Catalan political parties and civil society organisations have rebuilt their unity of action, which seemed broken during the time the Spanish Government was hesitating.

The Spanish Airport Authority (AENA) has announced that this coming winter season over 8.4 million seats will be on offer on flights out of Barcelona El Prat Airport, an increase of 6.8% compared to last year. Seats on intercontinental destinations have increased by 13.6% over last year. The number of flight operations (take-offs and landings) is anticipated to be 47,000: an increase of 4.1% to 2013. In contrast, the airport of Girona Costa Brava (northern Catalonia) has announced it will offer 16 routes this winter season, 20% less than last year. Ryanair has implemented the cuts it announced last May and will no longer be connecting Girona to London or Paris. Ryanair and Wizz Air will be the only airlines flying from Girona to Kiev, and only Ten Airwais will operate charter flights to Nador, Morocco. This summer, Girona airport connected passengers to 69 destinations.

Catalonia's National Alliance for Self-Determination, which brings together more than 3,000 civil society, business, cultural, sports and political organisations, pledged to make sure that the alternative participatory process scheduled on the 9^th of November will be a success, in terms of voter turnout and of other "great mobilisations". Despite the acknowledged limitations of this alternative vote that replaces the original consultation vote scheduled on the same day, the National Alliance has agreed to focus its collective efforts on this day's success, also backing "other forms of mobilisation that will strengthen citizen participation" in the self-determination process. Furthermore, the Alliance Coordinator, the veteran Christian-Democrat politician Joan Rigol, stressed that political parties will also focus on this day and will increase "coordination" to overcome recent tensions among them. The National Alliance will meet again after November 9 to discuss the next steps.

Spain's unemployment rate at the end of the third quarter stands at 23.67%, according to the latest Active Population Survey (EPA). The unemployment rate for Catalonia has fallen below 20% for the first time in the last 3 years and is set at 19.10%. The number of unemployed people in Catalonia has dropped by 44,400 in the third quarter of 2014, a decrease of 5.76% compared to the previous quarter. This is the biggest reduction since at least 2002, when the Spain's Statistical Institute began the series. Thanks to the creation of 69,100 new jobs in Catalonia over the last 12 months, there are now 34,800 more people employed in the third quarter. This makes Catalonia have the second highest unemployment drop in Spain, second only to Madrid Region (-48,200 people). The Catalan Minister for Business and Employment, Felip Puig, has called the figures are "encouraging" and "hopeful", although a 19.1% rate is still "very high".

The Constitutional Court has accepted the Spanish Government's appeal against the Catalan Executive' decree from December 2013 with which families in need are protected from their household electricity and gas being cut off by energy supply companies during winter months. The Catalan Government's measure aimed to fight the so-called 'energy poverty': people who cannot afford to pay for their energy bills because they do not get minimum income. The decree was not a cancellation of the bills but to allow those families to postpone the payment during the winter months. However, the Spanish Executive considered that the Catalan measure represented a "discrimination" against the citizens from other Autonomous Communities, who have to pay their energy bills on time. The appeal goes against Catalonia's political autonomy and is arbitrary. The Catalan Government stated it was "upset" by the ban and added that it will find an alternative way to help those families.

On Thursday, Oleguer Pujol, the youngest son of the former Catalan President, Jordi Pujol Soley, was formally indicted for alleged fiscal fraud and money laundering. The Spanish Police and the Public Prosecutor searched his house and several of his companies looking for files regarding real estate operations. This makes Oleguer the third son of the historical leader of conservative Catalan nationalism to be indicted for fiscal offenses. Furthermore, on Wednesday another judge indicted 11 people related to the former President's oldest son, Jordi Pujol Ferrusola – who seems to be at the centre of almost all the investigations. In addition, the judge has requested the freezing of his bank accounts in Andorra, from which he transferred €2.4 million to Mexico just after his father's fiscal fraud confession in July. On top of this, a judge from Liechtenstein is investigating the former Catalan President for alleged money laundering, after requests from the Spanish Police. Jordi Pujol senior has denied having had any bank account in the Alpine country.

The President of the Catalan Government and leader of the centre-right pro-Catalan State CiU, Artur Mas, and the President of the left-wing Catalan independence party ERC, Oriol Junqueras, met on Wednesday, after days of tensions among the parties supporting self-determination. The tensions have been mainly about how to raise the legal profile of the alternative participatory process scheduled on the 9^th of November, which replaces the original consultation vote, and about a common platform to run in early elections transformed into a 'de facto' referendum on independence. According to Junqueras, the two leaders decided to work on making sure that the alternative consultation vote is "a success". In addition, he said that Mas had requested that he leave the debate about the early elections for the days after the 9^th of November's vote, despite Junqueras insisting on an immediate electoral call.

Catalan author Jaume Cabré’s latest novel 'Jo confesso' has been translated into English and is finally hitting bookstores in the Anglophone world for the first time since its original publication in 2011. It was translated by Mara Faye Letham and published by Arcadia books. The novel, which this year won the Courrier International Prize for 'Best foreign novel', as well as several Catalan literature awards, has already been translated into Spanish, German, Italian and Chinese, among others. This is another success for Catalan literature, after the publication in English of 'Quadern gris' ('The Grey Notebook') by Josep Pla and the Joan Sales classic 'Incerta Glòria' ('Uncertain Glory'). Catalan literature is blossoming among English readers, thanks to the recent translations of several other classics.

938 of the 947 existing municipalities in Catalonia will host polling stations for the alternative consultation vote on independence scheduled for the 9^th of November, which replaces the original non-binding referendum. According to the Catalan Government, this represents 99.9% of Catalans being able to vote in their own neighbourhood, town or village, without having to go to a nearby municipality. The Catalan Government will be using its own venues to host the polling stations (mainly high-schools), but it lacks them in small towns. For this reason it requested that town halls cooperate and make municipal venues available for voting. 4 additional municipalities could be added to the final list. In addition, civil societies and parties will be able to campaign in 305 Catalan Government's venues between the 30^th of October and the 8^th of November.

The international rating agency Moody’s analyses the current political situation in Catalonia regarding the alternative consultation vote scheduled for the 9^th of November and the potential early elections. Moody’s considers that early Catalan Parliament elections are the most likely scenario, emphasising the Catalan Government’s commitment to respect the legal framework. In addition, it also considers “a common platform” with which pro-independence parties would run in the elections to be the most likely outcome. On top of this, Moody’s predicts the victory of such a common platform and that Catalonia would be in a “strong” position to negotiate a better fiscal deal within the current Constitution. However, in such scenario, Moody’s does not consider independence. In this vein, Catalonia’s credit rating is likely to improve while Spain’s would worsen.

Abadal wine cellar, in Pla de Bages appelation in central Catalonia, is the first in Europe to begin fermenting their grapes in big vats of dry Stone located outdoors, in the midst of the vineyards. The method is at once innovative and traditional, as it is the revival of an old tradition common in Europe during the 19^th century. This Monday, experts in the making of wine tasted the results of the first vintage, of which there are 600 bottles that will not be sold. Many described the wine as "exceptional". According to Abadal winemaker Miguel Palau, the method is highly unconventionalbecause it allows the uncommon option of blending grapes, here all 10 varieties, together and fermenting them outdoors. The result is apparently sharp and fresh, with balsamic notes due to its unusual fermentation.

The Catalan Government is disclosing further organisation details of the alternative participatory process that will take place on the 9^th of November, which is replacing the original consultation vote that was banned by Spanish authorities. The Catalan Minister for the Presidency, Francesc Homs, announced that 26,372 volunteers had already signed up on Monday afternoon to help in the organisation of the 9^th of November's vote. 20,000 were initially required, but Homs announced that registration would remain open because "the greater amount of resources we have, the better". In addition, high-schools will be the 700 Catalan Government's venues that will host the 6,000 voting booths. In the small rural towns and villages without high-schools, the Catalan Government is talking with municipalities to find alternatives.

After the civil society demonstration that took place on Sunday asking for the rebuilding of the unity of action and calling early elections, there has been some confusion regarding the Catalan Government's announcement of a "pre-agreement" on "a technical" unity for the alternative participatory process on the 9^th of November. In the morning the Catalan Government's Spokesperson, Francesc Homs, announced such a pre-agreement with the alternative left and radical independence CUP and was hoping the other parties would join it. The CUP refused such a pre-agreement. In addition, the left-wing Catalan independence party ERC and the Catalan green socialist and post-communist coalition ICV-EUiA met after knowing this announcement and asked for early elections. In addition, they said they will keep working for a shared proposal to strengthen the democratic guarantees for the new November 9.