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Scientists at the Universitat Autònoma de Barcelona (UAB) have found that an alteration of a neuronal gene program plays an essential role in the first stages of Alzheimer's disease and have developed a gene therapy which is effective on mice. The Catalan study occupies the front page of 'The Journal of Neuroscience'. Researchers have identified a new mechanism that regulates the expression of genes in the brain which are essential for the function of neuronal circuits involved in learning and memory. According to the new study, which was carried out by Dr. Carlos Saura's group at the UAB's Institute of Neurosciences (Institut de Neurociències), the alteration of a gene program mediating neuronal transmission and survival may underlie memory loss at early pathological stages of Alzheimer's disease (AD).

This week the ATP World Tour 500 series is in Barcelona for the 62^nd  edition of the Conde de Godó Trophy, officially named Barcelona Open Banc Sabadell 2014. Rafael Nadal is the defending champion looking to retain his title, but the world no. 1 faces tough competition as the tournament features a strong lineup of some of the best clay court specialists in the world including fellow compatriot and four time finalist David Ferrer, one of the strongest contenders for the title. The lineup also includes former local resident Fabio Fognini, ranked 13^th in the world and also a member of Real Club de Tennis Barcelona.

CataloniaVotes.eu is a new website set up to present the independence referendum, related news, a chronology of the last few years and facts about Catalan society, culture and economy to a foreign audience. The new webpage is in English, French and German and will also follow the day-to-day evolution of the referendum process, a consultation vote scheduled for the 9^th November. It has been launched by the Public Diplomacy Council of Catalonia (Diplocat), an organisation backed by the Catalan Government, the four Provincial Councils, universities, chambers of commerce, the main business-owner associations, trade unions, FC Barcelona and other public and private institutions.

On the 23^rd of April, Catalans celebrate one of their dearest festivities of the year: Sant Jordi (Saint George). The day is Catalonia's equivalent to Valentine's Day in the Anglo-Saxon world but it also represents a homage to literature and reading. Traditionally men offered red roses to their girlfriends or wives, and women offered a book in return. Nowadays, both men and women offer books and roses to those they love, whether their life partners, relatives, friends or even work colleagues. On almost every corner and on the main streets throughout Catalonia there are stands selling either roses or books. It is the day celebrating love but also the most important day for the publishing industry, selling around 8% of their yearly sales and advertising the latest gimmicks. In a country with 7.5 million people, some 7 million roses are sold and around 1.5 million books on this single day.

The number of foreign tourists who visited Catalonia between January and March reached 2.55 million people, which represents a 9.8% increase compared to the same period last year. In addition, the number of international visitors in March this year increased by 4.9% compared to the same month of 2013, despite the Easter holidays not being in March but in April in 2014. In the whole of Spain, 10.1 million foreigners visited the country in the first quarter of 2014, a 7.2% increase on the previous year. 25.3% of those visitors went to Catalonia, which ranked second among the Autonomous Communities. The Canaries topped the ranking with 3.12 million alien visitors, 31% of Spain's total.

Catalan Rumba is part of the Catalan cultural heritage as much as the traditional folk dance Sardana or the famous human towers known as Castellers. This musical genre, born on the streets of Barcelona during the Sixties, is often mistaken for flamenco or other popular Latin sounds. Musicians such as Peret, Antonio González ‘El Pescaílla’ or Gato Pérez were pioneers of this style and contributed to its institutional and social recognition. Different waves of groups and artists have left their footprint on the Catalan Rumba, which is experiencing a third new age defined by a more eclectic sound that reflects Barcelona’s multicultural and cosmopolitan lifestyle.

FC Barcelona are alive in La Liga. The Catalans ended a three-match losing streak this Sunday thanks to a 2-1 win over Athletic Club, who had taken the lead through Aduriz in the 50 minute. Barça missed a number of clear chances to equalise before Pedro pounced on a scuffed shot from Alexis to score from close range in the 71. Just minutes later Messi scored a second from a free kick to seal the win and keep Barça in the hunt for the Spanish League title.

Gareth Bale's goal five minutes from the end clinched the Spanish Cup for Real Madrid. Neymar almost sent the game into extra time in the final minute, but his shot hit the post. The 2014 Spanish Cup goes to Real Madrid after goals from Di María and Bale at the start and end of the match tipped the balance in their favour in this evening’s final. It was a cruel blow for FC Barcelona, who equalised with a Bartra in the second half. Barça are still the ‘king of cups’ with 26 titles, but this season the only major title they can still win is the domestic league.

The Spanish Foreign Affairs Minister, José Manuel García-Margallo, has accused the Catalan Government of "not telling the whole truth" regarding the EU membership of an independent Catalonia. García-Margallo stated a month ago that an independent Catalonia would "roam across space" and would be "excluded from the European Union for centuries of centuries". On Wednesday he referred to an expert report issued this week by the Catalan Government's Advisory Council for the National Transition (CATN), formed of prestigious academics. The CATN stated that EU Treaties do not include provisions for automatic expulsion nor for automatic admission. Therefore, the final decision would be reached in a negotiation with political and economic interests at play. For them, the most likely scenario is one with transition measures to guarantee the continuity of EU Law, the Schengen Area and the Euro, while waiting for the official admission of Catalonia to be accepted.

In the first two months of 2014 exports by Catalan companies increased by 2.2% on the same period last year, according to figures released on Wednesday by the Spanish Ministry for the Economy and Competitiveness. In fact, Catalan companies were behind 25.3% of all exports from Spain. Spain's exports in January and February reached €37.76 billion, a 4% increase on figures from the same period last year. In addition, the amount reached in the first two months of 2014 represents an historical record. The main industries behind those numbers are food, drinks, and tobacco, as well as manufacturing and automation.  The main markets for Spanish products were the UK, Portugal, the United States and Germany.

This Wednesday evening Valencia's Mestalla hosts the Spanish Cup Final and the Catalans face old rivals Real Madrid. It’s 63 days since FC Barcelona beat Real Sociedad in the semi-finals. It’ll be a peculiar final. There is no clear favourite, both sides are missing important players to injury, and for the first time in several years, these two teams are not the runaway leaders in La Liga. Barça come into the game following a disappointing week in which they were knocked out of the Champions League and suffered a serious setback in their quest to win La Liga. Real Madrid would appear to be heading in the opposite direction.

A Spokesperson for the European Commission was asked on Tuesday about the report issued on Monday by the Catalan Government's Advisory Council for National Transition, which stated that EU Treaties did not include any provision regarding the secession of a Member State and therefore the final decision would be a political one, following economic interests. They stated that the most likely scenario would be setting up transition measures guaranteeing the continuity of EU Law, Schengen and the Euro, while Catalonia's definitive EU membership was being negotiated. The European Commission - which acknowledged it only knew the report from the press – repeated that it will only give an analysis "upon the request of a Member State" and "on the basis of a detailed scenario". However, it also stated that "if a part territory of a Member State secedes", "EU Treaties no longer apply from the day of its independence" as it becomes "a third country". The Commission did not state the procedure, nor whether transition measures could guarantee the continuity of EU agreements.

The Port of Barcelona handled 10.7 million tons of goods during the first 3 months of 2014, which represents a 9% increase on the same period last year. Between January and March, all the types of transported goods posted a significant growth, and the same trend applies to the traffic of passengers, which grew by 9%. In the first quarter of the year, the number of vehicles transported grew by 5%, as did the number of containers, which reached 428,720 TEU. Container imports increased by 7% and exports by 3%. Container exports grew particularly to countries such as China (+31%), the United States (+17%), Morocco (+35%) and Mexico (+87%). The traffic of bulk liquids increased by 24%, particularly diesel and other fuel, as well as chemical products.

An independent Catalonia would benefit from transition measures that would guarantee the continuity of European Union agreements, thus staying within the Schengen Area and the Euro Zone. This is the most likely scenario in the event of independence, according to the Catalan Government's Advisory Council for the National Transition (CATN), which is a body formed of independent and prestigious academics. The CATN is issuing a series of reports on different aspects related to a hypothetical independent Catalan state. This expert group emphasises that there is "no legal basis" to conclude that Catalonia would be automatically expelled from the EU the moment it became independent, or to state that it would automatically join the Union as a new Member State. There is no provision in the Treaties and there are no precedents. The report concludes that Catalonia's EU membership will be decided in a negotiation process where political and economic interests will be at play.

FC Barcelona suffered their fifth defeat of the season away to Granada, losing by the only goal of the match. It was one of those games in which the ball just simply didn’t want to go in. The visitors shot no fewer than 29 times, but not one of those was enough to neutralise Brahimi’s opener. This was a very different game to the ones in San Sebastian and Valladolid. At the Nuevo Los Cármenes, Barça created threat after threat, but couldn’t secure the three points, or even just one, and now find that their destiny in La Liga is once again out of their hands.